EFEKTIVITAS TERAPI SISTEMIK DAN TOPIKAL DALAM PENGOBATAN MELASMA

https://doi.org/10.47539/gk.v12i2.136

Authors

  • Ni Made Ari Purwaningrum Universitas Udayana
  • Sang Ayu Arta Suryantari Universitas Udayana
  • Ni Luh Putu Ratih Vibriyanti Karna Universitas Udayana

Keywords:

Melasma, Efektivitas, Terapi sistemik, Terapi topikal.

Abstract

Melasma secara klinis digambarkan sebagai makula tidak teratur atau bercak hiperpigmentasi kronis yang umumnya terjadi pada wajah. Patogenesis melasma belum diketahui secara pasti namun berkaitan dengan paparan sinar ultraviolet (UV). Karena sifatnya yang kronis dan sering kambuh, melasma sulit untuk ditangani. Pengobatan yang tersedia saat ini seringkali memiliki efek samping yang tidak diinginkan dan hasil yang kurang optimal. Ulasan sistematis dibuat untuk merangkum efektivitas dan rekomendasi terapi sistemik dan topikal pada pengobatan melasma. Metode: Pencarian artikel di basis data PubMed, Cochrane library dan Medline dari Januari 2010 sampai Desember 2019. Hanya studi RCT, meta-analisis dan ulasan sistematis yang berfokus pada terapi sistemik dan topikal pada melasma yang dilakukan ekstraksi, analisis dan didiskusikan. Didapatkan total 17 artikel yang sesuai dengan kriteria tersebut. Terapi sistemik dan topikal yang diulas yaitu glutathione, asam traneksamat melatonin, cysteamine, flutamide, methimazole dan serum pengoreksi pigmen. Agen tersebut terbukti efektif, aman dan ditoleransi dengan baik. Berbagai bukti terapi sistemik, topikal dan kombinasi saat ini memiliki kelebihan dan kekurangan masing-masing. Pilihan modalitas pengobatan harus disesuaikan dengan tingkat keparahan, luas dan lokasi melasma. Pemahaman yang lebih baik tentang melasma melalui penelitian lebih lanjut dapat meningkatkan pilihan terapi dengan efek samping yang paling sedikit.

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Published

2020-12-29

How to Cite

Purwaningrum, N. M. A., Suryantari, S. A. A., & Karna, N. L. P. R. V. (2020). EFEKTIVITAS TERAPI SISTEMIK DAN TOPIKAL DALAM PENGOBATAN MELASMA. GEMA KESEHATAN, 12(2), 88–98. https://doi.org/10.47539/gk.v12i2.136

Issue

Vol. 12 No. 2 (2020): Desember 2020

Section

Literature review articles
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